Metavinculin modulates force transduction in cell adhesion sites
نویسندگان
چکیده
منابع مشابه
Comparative biochemical analysis suggests that vinculin and metavinculin cooperate in muscular adhesion sites.
Metavinculin, the muscle-specific splice variant of the cell adhesion protein vinculin, is characterized by a 68-amino acid insert within the C-terminal tail domain. The findings that mutations within this region correlate with hereditary idiopathic dilated cardiomyopathy in man suggest a specific contribution of metavinculin to the molecular architecture of muscular actin-membrane attachment s...
متن کاملCell adhesion force microscopy.
The adhesion forces of cervical carcinoma cells in tissue culture were measured by using the manipulation force microscope, a novel atomic force microscope. The forces were studied as a function of time and temperature for cells cultured on hydrophilic and hydrophobic polystyrene substrates with preadsorbed proteins. The cells attached faster and stronger at 37 degreesC than at 23 degreesC and ...
متن کاملTrophinin in cell adhesion and signal transduction.
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe ...
متن کاملCell adhesion and signal transduction in cancer
Introduction Cadherin cell-adhesion molecules and their intracellular binding partners, catenins, were discovered in the 1980s (for a review, see Takeichi, 1995). Interest in these molecules was sparked by the discovery that cadherins and, subsequently, catenins are important in the formation and metastasis of carcinomas (Behrens et al, 1989; Berx et al, 1998; Perl et al, 1998; Polakis, 2000). ...
متن کاملFriction-controlled traction force in cell adhesion.
The force balance between the extracellular microenvironment and the intracellular cytoskeleton controls the cell fate. We report a new (to our knowledge) mechanism of receptor force control in cell adhesion originating from friction between cell adhesion ligands and the supporting substrate. Adherent human endothelial cells have been studied experimentally on polymer substrates noncovalently c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20125-z